Summary

Name NRCAM
Full Name Neuronal cell adhesion molecule
Synonyms Nr-CAM, Neuronal surface protein Bravo, hBravo, NgCAM-related cell adhesion molecule, Ng-CAM-related | KIAA0343
Primary ID Q92823
Links - -
Type protein
Relations 5
Function Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ EPHB2up-regulates activity img/direct-activation.png phosphorylation NRCAM 0.303
Publications: 1 Organism: Homo Sapiens
+ EPHB1up-regulates activity img/direct-activation.png phosphorylation NRCAM 0.423
Publications: 1 Organism: Homo Sapiens
+ NRCAMup-regulates quantity img/direct-activation.png relocalization ANK2 0.726
Publications: 1 Organism: Rattus Norvegicus
Tissue: Central Nervous System
+ NRCAMup-regulates quantity img/direct-activation.png relocalization ANK3 0.711
Publications: 1 Organism: Rattus Norvegicus
Tissue: Central Nervous System
+ NRCAMup-regulates quantity img/direct-activation.png relocalization ANK1 0.524
Publications: 1 Organism: Rattus Norvegicus
Tissue: Central Nervous System