Summary

Name BCL2L2
Full Name Bcl-2-like protein 2
Synonyms Bcl2-L-2, Apoptosis regulator Bcl-W | BCLW, KIAA0271
Primary ID Q92843
Links - -
Type protein
Relations 9
Inhibitors ABT-737; Obatoclax mesylate; 4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexenyl]methyl]-1-piperazinyl]-N-[4-[[(2R)-4-(4-morpholinyl)-1-(phenylthio)butan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide
Function Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.

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Relations

Regulator Mechanism target score ℹ
+ ABT-737down-regulates img/direct_inhibition.png chemical inhibition BCL2L2 0.8
Publications: 2 Organism: Homo Sapiens
+ BCL2L2down-regulates img/direct_inhibition.png binding BAX 0.467
Publications: 1 Organism: Homo Sapiens
+ Obatoclax mesylatedown-regulates activity img/direct_inhibition.png chemical inhibition BCL2L2 0.8
Publications: 1 Organism: In Vitro
+ BCL2L2down-regulates img/direct_inhibition.png binding BAK1 0.455
Publications: 1 Organism: Homo Sapiens
+ BCL2L11down-regulates img/direct_inhibition.png binding BCL2L2 0.791
Publications: 1 Organism: Homo Sapiens
+ BADdown-regulates img/direct_inhibition.png binding BCL2L2 0.555
Publications: 1 Organism: Homo Sapiens
+ 4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexenyl]methyl]-1-piperazinyl]-N-[4-[[(2R)-4-(4-morpholinyl)-1-(phenylthio)butan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamidedown-regulates img/direct_inhibition.png chemical inhibition BCL2L2 0.8
Publications: 1 Organism: Homo Sapiens
+ BBC3down-regulates img/direct_inhibition.png binding BCL2L2 0.572
Publications: 1 Organism: Homo Sapiens