Summary

Name RIT1
Full Name GTP-binding protein Rit1
Synonyms Ras-like protein expressed in many tissues, Ras-like without CAAX protein 1 | RIBB, RIT, ROC1
Primary ID Q92963
Links - -
Type protein
Relations 4
Pathways Noonan syndrome
Function Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation.

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Relations

Regulator Mechanism target score ℹ
+ RALGDSup-regulates activity img/direct-activation.png binding RIT1 0.55
Publications: 1 Organism: Homo Sapiens
+ AFDNup-regulates activity img/direct-activation.png binding RIT1 0.2
Publications: 1 Organism: Homo Sapiens
+ RIT1up-regulates activity img/direct-activation.png binding BRAF 0.53
Publications: 1 Organism: Mus Musculus
Pathways:Noonan syndrome
+ RLFup-regulates activity img/direct-activation.png binding RIT1 0.313
Publications: 1 Organism: Homo Sapiens