Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273547 |
Thr573 |
IAKLKRPtALKKVIL |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
31314582 |
To explore the underlying mechanisms, we found that SLAN, a potential tumor suppressor, served as a substrate of Aurora-A and knockdown of SLAN induced immature cytokinesis. Aurora-A phosphorylates SLAN at T573 under the help of the scaffold protein 14-3-3η. Intriguingly, SLAN T573D or T573E inactivated and T573A activated the key cytokinesis regulator RhoA. |
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