Summary

Name MED12
Full Name Mediator of RNA polymerase II transcription subunit 12
Synonyms Activator-recruited cofactor 240 kDa component, ARC240, CAG repeat protein 45, Mediator complex subunit 12, OPA-containing protein, Thyroid hormone receptor-associated protein complex 230 kDa component, Trap230, Trinucleotide repeat-containing gene 11 protein | ARC240, CAGH45, HOPA, KIAA0192, TNRC11, TRAP230
Primary ID Q93074
Links - -
Type protein
Relations 1
Function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.

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Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png binding MED12 0.14
Publications: 1 Organism: Homo Sapiens