3.0
Summary
| Name |  MED12
|
| Full Name | Mediator of RNA polymerase II transcription subunit 12 |
| Synonyms | Activator-recruited cofactor 240 kDa component, ARC240, CAG repeat protein 45, Mediator complex subunit 12, OPA-containing protein, Thyroid hormone receptor-associated protein complex 230 kDa component, Trap230, Trinucleotide repeat-containing gene 11 protein | ARC240, CAGH45, HOPA, KIAA0192, TNRC11, TRAP230 |
| Primary ID | Q93074 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. |
binding
binding