| + |
EXT1 | up-regulates activity 
|
WNT8B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264020 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24860992 |
Decreased Ext1 was shown to reduce the level of Wnt8 and BMP4 signaling and disrupt ventral-specific gene expression. Ext1 function is required for maintenance of normal levels of BMP and wnt, as well as their target genes. In addition, expression of xbra and the establishment of ventral mesoderm depend upon normal levels of Ext1. These findings suggest that ext1-dependent synthesis of HSPG is critical for wnt and BMP signaling, mesodermal identity, and ventral pattern. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT8B | up-regulates 
binding
|
LRP6 |
0.602 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132027 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15578921 |
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT8B | up-regulates
binding
|
FZD3 |
0.609 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132024 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15578921 |
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
WNT8B
- 
- 