Summary

Name HDAC10
Full Name Polyamine deacetylase HDAC10
Synonyms HD10
Primary ID Q969S8
Links - -
Type protein
Relations 6
Inhibitors 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)-oxomethyl]phenoxy]ethyl]-2-benzofurancarboxamide; CUDC-101; (S)-N-Hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide; bufexamac; CUDC-907
Function Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11861901, PubMed:11726666, PubMed:11677242, PubMed:11739383). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039).

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Relations

Regulator Mechanism target score ℹ
+ 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)-oxomethyl]phenoxy]ethyl]-2-benzofurancarboxamidedown-regulates img/direct_inhibition.png chemical inhibition HDAC10 0.8
Publications: 1 Organism: Homo Sapiens
+ CUDC-101down-regulates activity img/direct_inhibition.png chemical inhibition HDAC10 0.8
Publications: 1 Organism: In Vitro
+ (S)-N-Hydroxy-4-(3-methyl-2-phenylbutanamido)benzamidedown-regulates activity img/direct_inhibition.png chemical inhibition HDAC10 0.8
Publications: 2 Organism: Homo Sapiens
+ bufexamacdown-regulates activity img/direct_inhibition.png chemical inhibition HDAC10 0.8
Publications: 1 Organism: Homo Sapiens
+ CUDC-907down-regulates img/direct_inhibition.png chemical inhibition HDAC10 0.8
Publications: 1 Organism: Homo Sapiens