3.0
Summary
| Name |  APOBEC3D
|
| Full Name | DNA dC->dU-editing enzyme APOBEC-3D |
| Synonyms | A3D | |
| Primary ID | Q96AK3 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against Vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | APOBEC3D | up-regulates 
|
Clearance_of_foreign intracellular_DNA | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |