3.0
Summary
| Name |  TMIGD2View Modifications |
| Full Name | Transmembrane and immunoglobulin domain-containing protein 2 |
| Synonyms | CD28 homolog, Immunoglobulin and proline-rich receptor 1, IGPR-1 | CD28H, IGPR1 |
| Primary ID | Q96BF3 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. {ECO:0000269|PubMed:22419821, ECO:0000269|PubMed:23784006}. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | IKBKB | up-regulates activity 
phosphorylation
|
TMIGD2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT1 | up-regulates activity
phosphorylation
|
TMIGD2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TMIGD2 | up-regulates activity
phosphorylation
|
AMPK | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |