Relation Results

Summary

Name RNF25
Full Name E3 ubiquitin-protein ligase RNF25
Synonyms RING finger protein 25, RING-type E3 ubiquitin transferase RNF25 |
Primary ID Q96BH1
Links - -
Type protein
Relations 2
Function E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). Stimulates transcription medi ...
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Type: Score: Layout: SPV 
0.4540.2RNF25NKD2Ub:E2

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Relations
Regulator
Mechanism
target
score ℹ
+ RNF25down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination NKD2 0.454
Identifier Residue Sequence Organism Cell Line
SIGNOR-271738 Homo sapiens HEK-293 Cell
pmid sentence
Here, we show that Naked2 is a short-lived protein with a half-life of 60 min caused by its rapid ubiquitin-mediated proteasomal degradation. Overexpression of TGF-alpha stabilizes Naked2 protein in an EGF receptor (EGFR)-independent manner; a physical interaction between the cytoplasmic tail of TGF-alpha and Naked2 is necessary and sufficient for this protection. We have identified a RING finger protein, AO7/RNF25, as a ubiquitin ligase for Naked2, and we have shown that overexpression of TGF-alpha reduces binding of AO7 to Naked2.
Publications: 1 Organism: Homo Sapiens
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination RNF25 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271207 Homo sapiens
pmid sentence
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t
Publications: 1 Organism: Homo Sapiens
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