Summary

Name APH1A
Full Name Gamma-secretase subunit APH-1A
Synonyms APH-1a, Aph-1alpha, Presenilin-stabilization factor | PSF
Primary ID Q96BI3
Links - -
Type protein
Relations 9
Function Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12297508, PubMed:12522139, PubMed:12763021, PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). Required for normal gamma-secretase assembly (PubMed:12522139, PubMed:12471034, PubMed:12763021, PubMed:19369254). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable).

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding APH1A 0.967
Publications: 3 Organism: Homo Sapiens
Tissue: Brain
+ form complex img/form-complex.png binding gamma-secretase 0.958
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PSENEN 0.962
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PSEN1 0.945
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png binding PSEN2 0.92
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png binding NCSTN 0.967
Publications: 1 Organism: Homo Sapiens
Tissue: Brain