Summary

Name OTULIN
Full Name Ubiquitin thioesterase otulin
Synonyms Deubiquitinating enzyme otulin, OTU domain-containing deubiquitinase with linear linkage specificity, Ubiquitin thioesterase Gumby | FAM105B
Primary ID Q96BN8
Links - -
Type protein
Relations 3
Pathways Ubiquitin activation
Function Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:26997266, PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:27523608, PubMed:27559085, PubMed:24726323, PubMed:24726327, PubMed:28919039). Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998). Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex (PubMed:23746843, PubMed:23806334). OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex (PubMed:26670046). Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed:27523608). In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PubMed:27523608). Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent pro-inflammatory signaling (PubMed:23806334).

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Relations

Regulator Mechanism target score ℹ
+ OTULINup-regulates quantity img/direct-activation.png cleavage UBB 0.649
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
+ OTULINup-regulates quantity img/direct-activation.png cleavage UBC 0.698
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
+ OTULINup-regulates quantity img/direct-activation.png cleavage Ubiquitin 0.698
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation