4.0
Summary
| Name |  ALKBH8
|
| Full Name | tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ALKBH8 |
| Synonyms | Alkylated DNA repair protein alkB homolog 8, Alpha-ketoglutarate-dependent dioxygenase ALKBH8, S-adenosyl-L-methionine-dependent tRNA methyltransferase ALKBH8 | ABH8 |
| Primary ID | Q96BT7 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323, PubMed:31079898). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys) (PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ALKBH8 | form complex 
binding
|
ALKBH8-TRM112 methyltransferase complex | 0.735 |
| Publications: | 1 | Organism: | Homo Sapiens | |