Relation Results

Summary

Name	CERS2
Full Name	Ceramide synthase 2
Synonyms	CerS2, LAG1 longevity assurance homolog 2, SP260, Sphingosine N-acyltransferase CERS2, EC 2.3.1.24, Tumor metastasis-suppressor gene 1 protein, Very-long-chain ceramide synthase CERS2, EC 2.3.1.297 \| LASS2, TMSG1
Primary ID	Q96G23
Links	- -
Type	protein
Relations	1
Function	Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very-long-chain fatty acyl-CoA (chain length C22-C27) (PubMed:17977534, PubMed:18165233, PubMed:18541923, PubMed:19728861, PubMed:20937905, PubMed:22144673, PubMed:22661289, PubMed:26887952, PubMed:29632068). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (By similarity) (PubMed:17977534, PubMed:18165233, PubMed:18541923, PubMed:19728861, PubMed:20937905, PubMed:22144673, PubMed:22661289, PubMed:26887952, PubMed:29632068). Plays a non-redundant role in the synthesis of ceramides with very-long-chain fatty acids in kidney, liver and brain. Regulates the abundance of myelin-specific sphingolipids galactosylceramide and sulfatide that affects myelin sheath architecture and motor neuron functions (By similarity). {ECO:0000250\|UniProtKB:Q924Z4, ECO:0000269\|PubMed:17977534, ECO:0000269\|PubMed:18165233, ECO:0000269\|PubMed:18541923, ECO:0000269\|PubMed:19728861, ECO:0000269\|PubMed:20937905, ECO:0000269\|PubMed:22144673, ECO:0000269\|PubMed:22661289, ECO:0000269\|PubMed:26887952, ECO:0000269\|PubMed:29632068}.