Summary

Name RMND5B
Full Name E3 ubiquitin-protein transferase RMND5B
Synonyms Protein RMD5 homolog B |
Primary ID Q96G75
Links - -
Type protein
Relations 1
Function Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). Catalytic activity of the complex is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972).

Viewer

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png ubiquitination RMND5B 0.2
Publications: 1 Organism: Homo Sapiens