Relation Results

Name	PAWR
Full Name	PRKC apoptosis WT1 regulator protein
Synonyms	Prostate apoptosis response 4 protein, Par-4 \| PAR4
Primary ID	Q96IZ0
Links	- -
Type	protein
Relations	3
Function	Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.