| + |
GSK3B | down-regulates quantity by destabilization 
phosphorylation
|
WT1 |
0.289 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277540 |
Ser208 |
GCHTPTDsCTGSQAL |
Homo sapiens |
|
| pmid |
sentence |
| 33184107 |
Glycogen synthase kinase 3β promoted phosphorylation of cugWT1 at S64, resulting in ubiquitination and degradation of the cugWT1 associated with the F-box-/- WD repeat-containing protein 8. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
PRKACA | down-regulates
phosphorylation
|
WT1 |
0.346 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53172 |
Ser365 |
KDCERRFsRSDQLKR |
Homo sapiens |
|
| pmid |
sentence |
| 9366517 |
Pka phosphorylated wt1 at ser-365 and ser-393 in vitro, as well as at additional sites, and this phosphorylation abolished the dna-binding activity of wt1 in vitro. Using wt1 mutants in which ser-365 and ser-393 were mutated to ala individually and in combination, we showed that phosphorylation of these sites was critical for inhibition of dna binding in vivo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53176 |
Ser393 |
KTCQRKFsRSDHLKT |
Homo sapiens |
|
| pmid |
sentence |
| 9366517 |
Pka phosphorylated wt1 at ser-365 and ser-393 in vitro, as well as at additional sites, and this phosphorylation abolished the dna-binding activity of wt1 in vitro. Using wt1 mutants in which ser-365 and ser-393 were mutated to ala individually and in combination, we showed that phosphorylation of these sites was critical for inhibition of dna binding in vivo. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CCNA1 | down-regulates quantity by repression 
transcriptional regulation
|
WT1 |
0.399 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255905 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19082485 |
This study identified WT1 as a repressed target of cyclin A1 and suggests that the suppression of WT1 in cyclin A1-overexpressing leukemias might play a role in the growth and suppression of apoptosis in these leukemic cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, Onco-fusion proteins in AML |
| + |
WT1 | down-regulates quantity by repression
transcriptional regulation
|
PAX2 |
0.618 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252298 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 7720589 |
A marked increase in WT1 protein levels coincided precisely with down-regulation of the Pax-2 gene in the individual precursor cells of the visceral glomerular epithelium, suggesting a direct effect of the WT1 repressor protein on Pax-2 regulatory elements. To examine whether WT1 could directly repress Pax-2 transcription, binding of WT1 to three high affinity sites in the 5' untranslated Pax-2 leader sequence was demonstrated by DNAseI footprinting analysis |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Kidney |
| Pathways: | Focal segmental glomerulosclerosis |
| + |
PAWR | down-regulates activity
binding
|
WT1 |
0.515 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240596 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 8943350 |
We identified par-4 (for prostate apoptosis response) as a WT1-interacting protein that itself functions as a transcriptional repressor. Functionally, par-4 inhibited transcription activated by WT1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAX2/TLE4 | down-regulates quantity by repression
transcriptional regulation
|
WT1 |
0.46 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252291 |
|
|
Mus musculus |
Podocyte |
| pmid |
sentence |
| 16631587 |
Recruitment of the groucho-related protein TLE4 may be involved in converting Pax2 into a transcriptional repressor of Wt1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Focal segmental glomerulosclerosis |
| + |
WT1 | up-regulates quantity by expression 
transcriptional regulation
|
AREG |
0.405 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251745 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10490105 |
The Wilms Tumor Suppressor WT1 Encodes a Transcriptional Activator of amphiregulin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAX2 | up-regulates quantity by expression
transcriptional regulation
|
WT1 |
0.618 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252290 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16631587 |
Cotransfection of Pax2 with the Wt1 reporter construct led to moderate activation of the Wt1 promoter. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Focal segmental glomerulosclerosis |
| + |
WT1 | up-regulates quantity by expression
transcriptional regulation
|
SOD1 |
0.268 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253898 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9867871 |
The human copper-zinc superoxide dismutase gene (SOD1) proximal promoter is regulated by Sp1, Egr-1, and WT1 via non-canonical binding sites. Egr-1 and two splicing variants of the Egr-related protein WT1 were able to transactivate the SOD1 promoter in co-transfection experiments. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WT1 | down-regulates
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255705 |
|
|
Homo sapiens |
HL-60 Cell |
| pmid |
sentence |
| 25601757 |
Cell proliferation was stimulated by the knockdown of either TET2 or WT1 gene in KG-1 cells, but not additively by the co-depletion of both genes. Collectively, these results suggest that TET2 and WT1 function in the same pathway to inhibit leukemia cell proliferation and colony formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AML-IDH/TET, Acute Myeloid Leukemia, DNMT3A in AML, Onco-fusion proteins in AML, AML-IDH/TET, IDH-TET in AML, miRNA in AML, NPM1_new |
| + |
TET2 | up-regulates activity
binding
|
WT1 |
0.461 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255703 |
|
|
Homo sapiens |
KG-1 Cell, HL-60 Cell |
| pmid |
sentence |
| 25601757 |
In this study, we demonstrate that WT1 binds directly to TET2 and recruits TET2 to specific genomic sites to regulate the expression of WT1 target genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AML-IDH/TET, Acute Myeloid Leukemia, DNMT3A in AML, AML-IDH/TET, IDH-TET in AML, miRNA in AML, NPM1_new |
| + |
USP9X | up-regulates quantity by stabilization
deubiquitination
|
WT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275614 |
|
|
|
|
| pmid |
sentence |
| 32152317 |
Here, we find that CDC14B antagonizes CDK1-mediated activating mitotic phosphorylation of the deubiquitinase USP9X at serine residue 2563, which we show to be essential for USP9X to mediate mitotic survival. Starting from an unbiased proteome-wide screening approach, we specify Wilms' tumor protein 1 (WT1) as the relevant substrate that becomes deubiquitylated and stabilized by serine 2563-phosphorylated USP9X in mitosis. |
|
| Publications: |
1 |
| + |
WT1 | up-regulates quantity by expression
transcriptional regulation
|
SLC29A4 |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268985 |
|
|
|
|
| pmid |
sentence |
| 18523561 |
ENT4 is transcriptionally activated by both isoforms of EWS/WT1 as evidenced by promoter-reporter and chromatin immunoprecipitation (ChIP) analyses. |
|
| Publications: |
1 |
| + |
WT1 | up-regulates quantity by expression
transcriptional regulation
|
NPHS1 |
0.503 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252299 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15504938 |
The Wilms tumor suppressor gene (WT1) is a zinc-finger-containing transcription factor that is coexpressed with NPHS1 in differentiated podocytes; gel shift binding assays demonstrate that a recombinant WT1 protein can bind and activate the 186-bp NPHS1 fragment in a sequence-specific manner |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Focal segmental glomerulosclerosis |
| + |
WT1 | up-regulates quantity by expression
transcriptional regulation
|
DNMT3A |
0.389 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255904 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23042785 |
Here, we show that Wilms' tumour 1 (WT1), a developmental master regulator that can also act as a tumour suppressor or oncoprotein, transcriptionally regulates the de novo DNA methyltransferase 3A (DNMT3A) and that cellular WT1 levels can influence DNA methylation of gene promoters genome-wide. we demonstrate that depletion of WT1 by short-interfering RNAs leads to reduced DNMT3A in Wilms' tumour cells and human embryonal kidney-derived cell lines. Chromatin immunoprecipitation assays demonstrate WT1 recruitment to the DNMT3A promoter region and reporter assays confirm that WT1 directly transactivates DNMT3A expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, DNMT3A in AML, Onco-fusion proteins in AML, miRNA in AML |
| + |
WT1 | up-regulates activity 
|
Urogenital_tract |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252302 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 10101119 |
The Wilms' Tumour gene WT1 has important functions during development. Knock-out mice were shown to have defects in the urogenital system and to die at embryonic day E13.5, probably due to heart failure. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Focal segmental glomerulosclerosis |
| + |
AMER1 | up-regulates
binding
|
WT1 |
0.45 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-185644 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19416806 |
Wtx binds wt1, a zinc-finger transcription factor that is inactivated in wilms tumor. / the ability of wtx to enhance wt1-mediated transactivation suggests a physiologically significant interaction between these 2 tumor suppressors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WT1 | up-regulates quantity by expression
transcriptional regulation
|
PODXL |
0.421 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252300 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11719225 |
Binding of WT1 to conserved elements within the Podocalyxin gene promoter results in potent transcriptional activation, and the specific expression pattern of Podocalyxin in the developing kidney mirrors that of WT1 itself. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Focal segmental glomerulosclerosis |
| + |
WT1 | up-regulates
binding
|
SRY |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-100345 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12970737 |
Here we report that wt1 binds to and acts synergistically with sry to activate transcription from a promoter containing sry-binding sites |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WT1 | down-regulates
binding
|
RBM4 |
0.374 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-149166 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16934801 |
Wilm's tumor protein 1 (wt1), a protein implicated in various cancers and developmental disorders, consists of two major isoforms: wt1(-kts), a transcription factor, and wt1(+kts), a post-transcriptional regulator that binds to rna and can interact with splicing components. Here we show that wt1 interacts with the novel splicing regulator rbm4. / we conclude that the (+kts) form of wt1 is able to inhibit the effect of rbm4 on alternative splicing. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WT1 | down-regulates quantity by repression
transcriptional regulation
|
REN |
0.433 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252296 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18496514 |
Here, we show that a splice variant of the Wilms' tumor protein lacking three amino acids WT1(-KTS) suppresses renin gene transcription |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Focal segmental glomerulosclerosis |
3.0
WT1
- 
- 