Summary

Name THOC3
Full Name THO complex subunit 3
Synonyms Tho3, TEX1 homolog, hTREX45 |
Primary ID Q96J01
Links - -
Type protein
Relations 1
Function Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.

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Relations

Regulator Mechanism target score ℹ
+ THOC3form complex img/form-complex.png binding TREX complex 0.92
Publications: 1 Organism: Homo Sapiens