| + |
HERC2 | down-regulates quantity by destabilization 
polyubiquitination
|
NEURL4 |
0.469 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272921 |
|
|
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 22261722 |
NEURL4 is a substrate of HERC2, and together these results indicate that the NEURL4-HERC2 complex participates in the ubiquitin-dependent regulation of centrosome architecture. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272910 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22261722 |
Here we used interaction proteomics to identify the E3 ligase HERC2 and the neuralized homologue NEURL4 as novel interaction partners of the centrosomal protein CP110.NEURL4 is a substrate of HERC2, and together these results indicate that the NEURL4-HERC2 complex participates in the ubiquitin-dependent regulation of centrosome architecture. In further support of the possibility that NEURL4 is regulated by proteasomal degradation, we detected robust ubiquitylation of a FLAG-NEURL4 protein in HEK293T cells (Fig. 5B). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
3.0
NEURL4
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