Relation Results

Summary

Name FCRL2
Full Name Fc receptor-like protein 2
Synonyms FcR-like protein 2, FcRL2, Fc receptor homolog 2, FcRH2, IFGP family protein 4, Immunoglobulin receptor translocation-associated protein 4, SH2 domain-containing phosphatase anchor protein 1, CD antigen CD307b | FCRH2, IFGP4, IRTA4, SPAP1
Primary ID Q96LA5
Links - -
Type protein
Relations 1
Function May have an regulatory role in normal and neoplastic B cell development. {ECO:0000269|PubMed:11493702}.

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Type: Score: Layout: SPV 
0.2MARCHF9FCRL2

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Relations
Regulator
Mechanism
target
score ℹ
+ MARCHF9down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination FCRL2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271543 Homo sapiens B-lymphocyte Cell Line
pmid sentence
MARCH9, a member of the RING-CH family of transmembrane E3 ubiquitin ligases, down-regulates CD4, major histocompatibility complex-I (MHC), and ICAM-1 in lymphoid cells. To identify novel MARCH9 substrates, we used high throughput flow cytometry and quantitative mass spectrometry by stable isotope labeling by amino acids in cell culture (SILAC) to determine the differential expression of plasma membrane proteins in a MARCH9-expressing B cell line. This combined approach identified 13 potential new MARCH9 targets. 
Publications: 1 Organism: Homo Sapiens
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