| + |
FBXL18 | down-regulates quantity by destabilization 
binding
|
FBXL7 |
0.654 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272448 |
|
|
Mus musculus |
MLE-12 Cell |
| pmid |
sentence |
| 25654763 |
F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7.. Here, we identified that an orphan F-box protein, Fbxl18, targets Fbxl7 for its polyubiquitylation and proteasomal degradation. Lys 109 within Fbxl7 is an essential acceptor site for ubiquitin conjugation by Fbxl18. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FBXL18 | down-regulates quantity by destabilization
binding
|
ERCC3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277434 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 30762924 |
These results led us to propose a model that spironolactone may trigger the phosphorylation of XPB at Ser90 by CDK7, which promotes the recognition and polyubiquitination of XPB by SCFFBXL18 for proteasomal degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXL18 | up-regulates activity 
binding
|
Cullin 1-RBX1-Skp1 |
0.563 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272449 |
|
|
Mus musculus |
MLE-12 Cell |
| pmid |
sentence |
| 25654763 |
F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7.. Here, we identified that an orphan F-box protein, Fbxl18, targets Fbxl7 for its polyubiquitylation and proteasomal degradation. Lys 109 within Fbxl7 is an essential acceptor site for ubiquitin conjugation by Fbxl18. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
4.0
FBXL18
- 
- 