| Identifier | 
									Residue | 
									Sequence | 
									Organism | 
									Cell Line | 
								 
							
								
								
									| SIGNOR-254944 | 
									 | 
									 | 
									Homo sapiens | 
									Embryonic Stem Cell | 
								
								 
									| pmid | 
									sentence | 
								 
								 
									| 17068183 | 
								
									 To enhance our understanding of the molecular basis of this differentiation event in humans, we used a functional genomics approach involving RNA interference-mediated suppression of OCT4 function in a human ESC line and analysis of the resulting transcriptional profiles to identify OCT4-dependent genes in human cells. We detected altered expression of >1,000 genes, including targets regulated directly by OCT4 either positively (NANOG, SOX2, REX1, LEFTB, LEFTA/EBAF DPPA4, THY1, and TDGF1) or negatively (CDX2, EOMES, BMP4, TBX18, Brachyury [T], DKK1, HLX1, GATA6, ID2, and DLX5), as well as targets for the OCT4-associated stem cell regulators SOX2 and NANOG.  | 
								 
						 
                     |