Relation Results

Summary

Name KREMEN1
Full Name Kremen protein 1
Synonyms Dickkopf receptor, Kringle domain-containing transmembrane protein 1, Kringle-containing protein marking the eye and the nose | KREMEN, KRM1
Primary ID Q96MU8
Links - -
Type protein
Relations 2
Function Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LR ...
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Type: Score: Layout: SPV 
0.6390.838KREMEN1LRP6DKK1

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Relations
Regulator
Mechanism
target
score ℹ
+ KREMEN1up-regulates img/indirect-activation.png LRP6 0.639
Identifier Residue Sequence Organism Cell Line
SIGNOR-88891 Homo sapiens
pmid sentence
Dkk1 has been shown to inhibit wnt signalling by binding to and antagonizing lrp5/6. Here we show that the transmembrane proteins kremen1 and kremen2 are high-affinity dkk1 receptors that functionally cooperate with dkk1 to block wnt/beta-catenin signalling.
Publications: 1 Organism: Homo Sapiens
+ DKK1up-regulates img/direct-activation.png binding KREMEN1 0.838
Identifier Residue Sequence Organism Cell Line
SIGNOR-88838 Homo sapiens
pmid sentence
Dkk1 has been shown to inhibitwnt by binding to and antagonizing lrp5/6. Here we show that the transmembrane proteins kremen1 and kremen2 are high-affinity dkk1 receptors that functionally cooperate with dkk1 to blockwnt/betBeta-catenin. Kremen2 forms a ternary complex with dkk1 and lrp6, and induces rapid endocytosis and removal of thewntreceptor lrp6 from the plasma membrane.
Publications: 1 Organism: Homo Sapiens
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