3.0
Summary
| Name |  ADGRA2
|
| Full Name | Adhesion G protein-coupled receptor A2 |
| Synonyms | G-protein coupled receptor 124, Tumor endothelial marker 5 | GPR124, KIAA1531, TEM5 |
| Primary ID | Q96PE1 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628). {ECO:0000250|UniProtKB:Q91ZV8, ECO:0000269|PubMed:16982628, ECO:0000269|PubMed:28289266, ECO:0000269|PubMed:30026314}. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | hsa-miR-138-5p | down-regulates quantity by repression 
post transcriptional regulation
|
ADGRA2 | 0.4 |
| Publications: | 1 | Organism: | Homo Sapiens | |