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Summary
| Name |  RNF157
|
| Full Name | E3 ubiquitin ligase RNF157 |
| Synonyms | RING finger protein 157, RING-type E3 ubiquitin transferase RNF157 | KIAA1917 |
| Primary ID | Q96PX1 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469). Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469). May act as a scaffold molecule to regulate this process (PubMed:25342469). Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (PubMed:28655764). |
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ubiquitination