+ |
CDK1 | down-regulates activity
phosphorylation
|
ATAD5 |
0.241 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266410 |
Ser653 |
TVPFDSEsPIRMKFT |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
31875566 |
To determine whether mitotic CDK phosphorylates ATAD5, a CDK1 inhibitor (RO3306) was applied to nocodazole-arrested cells (Figure S3F). CDK1 inhibition resulted in a loss of S653 phosphorylation (Figure S3F). These data meant that the S653 residue in the BET BD of ATAD5 is phosphorylated by mitotic CDK. This result suggested that the BRD4-ATAD5 interaction is inhibited during mitosis. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
ATAD5 | up-regulates
binding
|
BRD4 |
0.357 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266412 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
31875566 |
ATAD5 Interacts with BRD4 through a Conserved BET Protein-Binding Domain. BRD4-ATAD5 binds to acetyl-histones in nascent chromatin. BRD4 release from chromatin correlates with PCNA unloading. Disruption of the interaction between BRD4 and acetyl-histones or between BRD4 and ATAD5 reduces the PCNA amount on chromatin. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |