| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280958 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22118932 |
The process of Intraflagellar Transport (IFT) is of central importance for both the assembly and maintenance of cilia, as it delivers building blocks from their site of synthesis in the cell body to the ciliary assembly site at the tip of the cilium. A key player in this process is the multi-subunit IFT-complex, which acts as an adapter between the motor proteins required for movement and the ciliary cargo proteins. With the exception of IFT43, the members of the IFT-A complex are large proteins with molecular masses above 120 kDa. IFT144, IFT140, IFT122 and IFT121 protein sequences are predicted to have a remarkably similar domain organization with the N-terminal regions containing WD-repeats that are known to fold into β-propellers, while the C-terminal part is predicted to contain α-helical TPR repeats (Fig. 1). |
|
4.0
IFT140
- 
- 
binding