| + |
NODAL | up-regulates quantity by expression 
transcriptional regulation
|
LIF |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251941 |
|
|
Homo sapiens |
GBM-8401 Cell |
| pmid |
sentence |
| 20383200 |
Nodal induced LIF and Cripto-1 expressions through Smad2 signaling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NODAL | up-regulates quantity by expression
transcriptional regulation
|
TDGF1 |
0.646 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251942 |
|
|
Homo sapiens |
GBM-8401 Cell |
| pmid |
sentence |
| 20383200 |
Nodal induced LIF and Cripto-1 expressions through Smad2 signaling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NODAL | up-regulates
|
Apoptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251934 |
|
|
Homo sapiens |
Epithelial Ovarian Cancer Cell |
| pmid |
sentence |
| 15531507 |
Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NODAL | up-regulates activity 
binding
|
ACVR1C |
0.621 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251936 |
|
|
Homo sapiens |
Epithelial Ovarian Cancer Cell |
| pmid |
sentence |
| 15531507 |
Human activin receptor-like kinase 7 (ALK7), a type I receptor for Nodal. activation of the Nodal-ALK7 signaling pathway leads to induction of apoptosis and inhibition of cell proliferation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NODAL | up-regulates activity
binding
|
ACVR1B |
0.627 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251939 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19874624 |
Nodal effects are dependent upon interactions with Cripto, a small cysteine-rich extracellular protein that is attached to the plasma membrane through a glycosyl phosphatidyl inositol linkage. Cripto interacts with Nodal and ALK4, independently, and promotes the formation of a stable high affinity complex with activin type II receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NODAL | up-regulates quantity by expression
transcriptional regulation
|
MMP2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251940 |
|
|
Homo sapiens |
GBM-8401 Cell |
| pmid |
sentence |
| 20383200 |
Ectopic expression of Nodal or activation of Nodal signaling by addition of rNodal increased MMP-2 protein level and cell invasion. the expression level of Nodal correlates well with MMP-2 expression and cell invasion. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TDGF1 | up-regulates activity
binding
|
NODAL |
0.646 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251937 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19874624 |
Nodal effects are dependent upon interactions with Cripto, a small cysteine-rich extracellular protein that is attached to the plasma membrane through a glycosyl phosphatidyl inositol linkage. Cripto interacts with Nodal and ALK4, independently, and promotes the formation of a stable high affinity complex with activin type II receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NODAL | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256656 |
|
|
Homo sapiens |
Epithelial Ovarian Cancer Cell |
| pmid |
sentence |
| 15531507 |
Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NODAL | down-regulates 
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251935 |
|
|
Homo sapiens |
Epithelial Ovarian Cancer Cell |
| pmid |
sentence |
| 15531507 |
Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NODAL
- 
- 