3.0
Summary
| Name |  SPSB2
|
| Full Name | SPRY domain-containing SOCS box protein 2 |
| Synonyms | SSB-2, Gene-rich cluster protein C9 | GRCC9, SSB2 |
| Primary ID | Q99619 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). {ECO:0000269|PubMed:15601820, ECO:0000269|PubMed:21199876}. |
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