Relation Results

Name	KIR2DL4
Full Name	Killer cell immunoglobulin-like receptor 2DL4
Synonyms	CD158 antigen-like family member D, G9P, Killer cell inhibitory receptor 103AS, KIR-103AS, MHC class I NK cell receptor KIR103AS \| CD158D, KIR103AS
Primary ID	Q99706
Links	- -
Type	protein
Relations	1
Function	Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734). May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells (PubMed:10190900, PubMed:16366734). Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent proinflammatory response (PubMed:20179272).