Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272673 |
|
|
in vitro |
|
pmid |
sentence |
14559152 |
SEPT5_v2 is highly homologous to another septin, SEPT5, which was recently identified as a target for parkin-mediated ubiquitination. SEPT5_v2 binds to parkin at the amino terminus and in the ring finger domains.Parkin ubiquitinates SEPT5_v2 in vitro, and both SEPT5_v1 and SEPT5_v2 accumulate in brains of patients with ARJP, suggesting that parkin is essential for the normal metabolism of these proteins. |
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