+ |
TRAF6 | down-regulates activity
ubiquitination
|
ECSIT |
0.783 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260370 |
|
|
Mus musculus |
|
pmid |
sentence |
21525932 |
Here we demonstrate that engagement of a subset of Toll-like receptors (TLR1, TLR2 and TLR4) results in the recruitment of mitochondria to macrophage phagosomes and augments mROS production. This response involves translocation of a TLR signalling adaptor, tumour necrosis factor receptor-associated factor 6 (TRAF6), to mitochondria, where it engages the protein ECSIT (evolutionarily conserved signalling intermediate in Toll pathways), which is implicated in mitochondrial respiratory chain assembly. Interaction with TRAF6 leads to ECSIT ubiquitination and enrichment at the mitochondrial periphery, resulting in increased mitochondrial and cellular ROS generation |
|
Publications: |
1 |
Organism: |
Mus Musculus |
+ |
ECSIT | up-regulates activity
binding
|
MAVS |
0.439 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260371 |
|
|
Homo sapiens |
|
pmid |
sentence |
22588174 |
ECSIT interacts with IPS-1|ECSIT enhances IPS-1-mediated IFN-Beta promoter activation |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
TRIM59 | down-regulates activity
binding
|
ECSIT |
0.534 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260369 |
|
|
Homo sapiens |
HeLa Cell, HEK-293T Cell |
pmid |
sentence |
22588174 |
In this study, we showed that one of the TRIM family ubiquitin ligases, TRIM59, interacts with ECSIT as an adaptor protein required for the TLR-mediated transduction pathway. The B-box and RING domains of TRIM59 are important for interaction with ECSIT.|ECSIT enhances IPS-1-mediated IFN-Beta promoter activation.|Luciferase reporter assays using reporter plasmids including NF-kappaB responsive element, interferon beta (IFN-beta) promoter and interferon-sensitive response element (ISRE) showed that overexpression of TRIM59 repressed their transcriptional activities, whereas knockdown of TRIM59 enhanced their transcriptional activities. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |