Summary

Name SELENOS
Full Name Selenoprotein S
Synonyms SelS, VCP-interacting membrane protein | SELS, VIMP
Primary ID Q9BQE4
Links - -
Type protein
Relations 2
Function Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding DERL1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding VCP 0.2
Publications: 1 Organism: Homo Sapiens