Summary

Name SLC30A2
Full Name Proton-coupled zinc antiporter SLC30A2
Synonyms Solute carrier family 30 member 2, Zinc transporter 2, ZnT-2 | ZNT2
Primary ID Q9BRI3
Links - -
Type protein
Relations 4
Function Electroneutral proton-coupled antiporter concentrating zinc ions into a variety of intracellular organelles including endosomes, zymogen granules and mitochondria. Thereby, plays a crucial role in cellular zinc homeostasis to confer upon cells protection against its potential cytotoxicity (PubMed:17065149, PubMed:21289295, PubMed:22733820, PubMed:25657003, PubMed:25808614, PubMed:30893306). Regulates the zinc concentration of milk, through the transport of zinc ions into secretory vesicles of mammary cells (PubMed:19496757). By concentrating zinc ions into lysosomes participates to lysosomal-mediated cell death during early mammary gland involution (PubMed:25808614).

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding ZNT1-ZNT2 proton-coupled zinc antiporter complex 0.418
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding ZNT2-ZNT3 proton-coupled zinc antiporter complex 0.345
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding ZNT2-ZNT4 proton-coupled zinc antiporter complex 0.329
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding ZNT2-ZNT10 proton-coupled zinc antiporter complex 0.413
Publications: 1 Organism: Homo Sapiens