Relation Results

Summary

Name TRIM56
Full Name E3 ubiquitin-protein ligase TRIM56
Synonyms RING finger protein 109, Tripartite motif-containing protein 56 | RNF109
Primary ID Q9BRZ2
Links - -
Type protein
Relations 2
Function E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity by mediating ubiquitination of CGAS and STING1 (PubMed:21289118, PubMed ...
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Type: Score: Layout: SPV 
0.20.2Ub:E2TRIM56STING1

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Relations
Regulator
Mechanism
target
score ℹ
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination TRIM56 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270961 Homo sapiens
pmid sentence
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t
Publications: 1 Organism: Homo Sapiens
+ TRIM56up-regulates activity img/direct-activation.png ubiquitination STING1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-278621 Homo sapiens
pmid sentence
In contrast, we found that TRIM56 preferentially promoted K63 linked ubiquitination of the same lysine residue of STING that was important for the dimer formation and TBK1 activation.|Specifically, TRIM56 induces STING dimerization during dsDNA triggered signaling to potentiate antiviral responses while RNF5 may induce degradation of mitochondrial STING to suppress RLR induced antiviral responses.The findings that TRIM56 failed to interact with dsDNA and that there was no colocalization between TRIM56 and dsDNA within cells suggest that TRIM56 is unlikely to be a dsDNA sensor, and instead facilitates the STING function by ubiquitination.
Publications: 1 Organism: Homo Sapiens
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