Summary

Name TRIM56
Full Name E3 ubiquitin-protein ligase TRIM56
Synonyms RING finger protein 109, Tripartite motif-containing protein 56 | RNF109
Primary ID Q9BRZ2
Links - -
Type protein
Relations 1
Function E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity by mediating ubiquitination of CGAS and STING1 (PubMed:21289118, PubMed:29426904). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Also mediate monoubiquitination of CGAS, thereby promoting CGAS oligomerization and subsequent activation (PubMed:29426904). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES (PubMed:22948160). Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).

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Relations

Regulator Mechanism target score ℹ
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination TRIM56 0.2
Publications: 1 Organism: Homo Sapiens