Summary

Name THUMPD2
Full Name U6 snRNA (guanine-N(2))-methyltransferase THUMPD2
Synonyms THUMP domain-containing protein 2 | C2orf8
Primary ID Q9BTF0
Links - -
Type protein
Relations 1
Function Catalytic subunit of the THUMPD2-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotides, most probably at position 72 (m2G72), in the U6snRNA of the major spliceosome (PubMed:37283053). This modification in the U6 snRNA affects the constitutive splicing efficiency of introns that have suboptimal splice sites and can impact final mRNA levels (PubMed:37283053).

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Relations

Regulator Mechanism target score ℹ
+ THUMPD2form complex img/form-complex.png binding THUMPD2-TRM112 methyltransferase complex 0.2
Publications: 1 Organism: Homo Sapiens