Summary

Name PI4K2A
Full Name Phosphatidylinositol 4-kinase type 2-alpha
Synonyms Phosphatidylinositol 4-kinase type II-alpha
Primary ID Q9BTU6
Links - -
Type protein
Relations 3
Inhibitors adenosine
Function Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation CLSPN 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png PI4K2A 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition PI4K2A 0.14
Publications: 1 Organism: In Vitro