4.0
Summary
| Name |  PI4K2AView Modifications |
| Full Name | Phosphatidylinositol 4-kinase type 2-alpha |
| Synonyms | Phosphatidylinositol 4-kinase type II-alpha |
| Primary ID | Q9BTU6 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Inhibitors | adenosine |
| Function | Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PI4K2A | down-regulates 
phosphorylation
|
CLSPN | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ATR | down-regulates 
|
PI4K2A | 0.278 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | adenosine | down-regulates activity
chemical inhibition
|
PI4K2A | 0.8 |
| Publications: | 1 | Organism: | In Vitro | |