4.0
Summary
| Name |  TRAF4View Modifications |
| Full Name | TNF receptor-associated factor 4 |
| Synonyms | Cysteine-rich domain associated with RING and Traf domains protein 1, Metastatic lymph node gene 62 protein, MLN 62, RING finger protein 83 | CART1, MLN62, RNF83 |
| Primary ID | Q9BUZ4 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | TRAF4 | down-regulates quantity by destabilization 
ubiquitination
|
SMURF2 | 0.362 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CHUK | down-regulates
phosphorylation
|
TRAF4 | 0.384 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Ub:E2 | up-regulates activity 
ubiquitination
|
TRAF4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |