Summary

Name KATNB1
Full Name Katanin p80 WD40 repeat-containing subunit B1
Synonyms Katanin p80 subunit B1, p80 katanin |
Primary ID Q9BVA0
Links - -
Type protein
Relations 4
Function Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

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Relations

Regulator Mechanism target score
+ down-regulates img/indirect_inhibition.png Microtubule_polimerization 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding KATNB1 0.608
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding KATNA1 0.784
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding KATNB1 0.784
Publications: 1 Organism: Homo Sapiens