3.0
Summary
| Name |  TRIM62View Modifications |
| Full Name | E3 ubiquitin-protein ligase TRIM62 |
| Synonyms | Tripartite motif-containing protein 62 | |
| Primary ID | Q9BVG3 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C-type lectin receptors; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways (PubMed:26488816). E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2 (PubMed:23402750). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | TRIM62 | up-regulates activity 
polyubiquitination
|
CARD9 | 0.525 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Ub:E2 | up-regulates activity
ubiquitination
|
TRIM62 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRIM62 | down-regulates quantity by destabilization 
polyubiquitination
|
TRIM62 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |