Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-269816 |
|
|
Homo sapiens |
|
pmid |
sentence |
33941892 |
Mechanistically, PHF7 localizes to cardiac super enhancers in fibroblasts, and through cooperation with the SWI/SNF complex, it increases chromatin accessibility and transcription factor binding at these sites. Furthermore, PHF7 recruits cardiac transcription factors to activate a positive transcriptional autoregulatory circuit in reprogramming. PHF7 interacts with SMARCD3 to promote reprogramming. |
|