3.0
Summary
| Name |  NFKBIZ
|
| Full Name | NF-kappa-B inhibitor zeta |
| Synonyms | I-kappa-B-zeta, IkB-zeta, IkappaBzeta, IL-1 inducible nuclear ankyrin-repeat protein, INAP, Molecule possessing ankyrin repeats induced by lipopolysaccharide, MAIL | IKBZ, INAP, MAIL |
| Primary ID | Q9BYH8 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (By similarity). |
transcriptional regulation