Summary

Name UBXN6
Full Name UBX domain-containing protein 6
Synonyms UBX domain-containing protein 1 | UBXD1, UBXDC2
Primary ID Q9BZV1
Links - -
Type protein
Relations 1
Function May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes (PubMed:26475856). As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation (PubMed:21822278, PubMed:23335559). It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:19275885). Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). {ECO:0000269|PubMed:19275885, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26475856, ECO:0000269|PubMed:27753622}.

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Relations

Regulator Mechanism target score ℹ
+ SMURF1 img/unknown.png ubiquitination UBXN6 0.2
Publications: 1 Organism: In Vitro