Relation Results

Summary

Name UCK2
Full Name Uridine-cytidine kinase 2
Synonyms UCK 2, Cytidine monophosphokinase 2, Testis-specific protein TSA903, Uridine monophosphokinase 2 | UMPK
Primary ID Q9BZX2
Links - -
Type protein
Relations 3
Function Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonuc ...
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Type: Score: Layout: SPV 
0.80.80.2UCK2uridine 5'-monophosphate(2-)cytidine 5'-monophosphate(2-)METTL3

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Relations
Regulator
Mechanism
target
score ℹ
+ UCK2up-regulates quantity img/direct-activation.png chemical modification uridine 5'-monophosphate(2-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-275860
pmid sentence
Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases.|We have cloned the cDNA of two human UCKs. The approximately 30-kDa proteins, named UCK1 and UCK2, were expressed in Escherichia coli and shown to catalyze the phosphorylation of Urd and Cyd. The enzymes did not phosphorylate deoxyribonucleosides or purine ribonucleosides.
Publications: 1
+ UCK2up-regulates quantity img/direct-activation.png chemical modification cytidine 5'-monophosphate(2-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-275861
pmid sentence
Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases.|We have cloned the cDNA of two human UCKs. The approximately 30-kDa proteins, named UCK1 and UCK2, were expressed in Escherichia coli and shown to catalyze the phosphorylation of Urd and Cyd. The enzymes did not phosphorylate deoxyribonucleosides or purine ribonucleosides.
Publications: 1
+ METTL3up-regulates quantity by stabilization img/direct-activation.png post transcriptional regulation UCK2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-275862
pmid sentence
Furthermore, the m6A modification regulated by METTL3 led to UCK2 increased messenger RNA (mRNA) stability in melanoma cancer. Functional and mechanistic experiments indicated that UCK2 enhanced the metastasis of melanoma cancer cells through the WNT/β-catenin pathway.
Publications: 1
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