| Name
|
 TRIM7
|
| Full Name |
E3 ubiquitin-protein ligase TRIM7 |
| Synonyms |
Glycogenin-interacting protein, RING finger protein 90, Tripartite motif-containing protein 7 | GNIP, RNF90 |
| Primary ID |
Q9C029 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
1 |
| Function |
E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation (PubMed:25851810). Promotes the TLR4-mediated signaling activation through its E3 ligase domain leading to production of pro-inflammatory cytokines and type I interferon (By similarity). Also plays a negative role in the regulation of exogenous cytosolic DNA virus-triggered immune response. Mechanistically, enhances the 'Lys-48'-linked ubiquitination of STING1 leading to its proteasome-dependent degradation (PubMed:32126128). |
3.0
ubiquitination