| + |
PHACTR1 | up-regulates activity 
binding
|
PP1 |
0.553 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264656 |
|
|
Homo sapiens |
HUVEC Cell |
| pmid |
sentence |
| 21939755 |
Phactr-1 was previously identified as protein phosphatase 1 (PP1) α-interacting protein that possesses actin-binding domains. We showed that Phactr-1 depletion decreased PP1 activity, disrupted the fine-tuning of actin polymerization and impaired lamellipodial dynamics. Taken together our results strongly suggest that Phactr-1 is a key component in the angiogenic process. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHACTR1 | up-regulates activity
binding
|
PPP1CA |
0.553 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260062 |
|
|
Homo sapiens |
HUVEC Cell |
| pmid |
sentence |
| 21939755 |
Phactr-1 was previously identified as protein phosphatase 1 (PP1) α-interacting protein that possesses actin-binding domains. We showed that Phactr-1 depletion decreased PP1 activity, disrupted the fine-tuning of actin polymerization and impaired lamellipodial dynamics. Taken together our results strongly suggest that Phactr-1 is a key component in the angiogenic process. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NRP1 | up-regulates quantity by expression 
transcriptional regulation
|
PHACTR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260061 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21939755 |
Recently, we identified a new Vascular Endothelial Growth Factor (VEGF)-A(165)-induced gene Phactr-1, (Phosphatase Actin Regulator-1). We found that neuropilin-1 (NRP-1) and VEGF-R1 depletion inhibited Phactr-1 mRNA expression while NRP-2 and VEGF-R2 depletion had no effect. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FLT1 | up-regulates quantity by expression
transcriptional regulation
|
PHACTR1 |
0.264 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260060 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21939755 |
Recently, we identified a new Vascular Endothelial Growth Factor (VEGF)-A(165)-induced gene Phactr-1, (Phosphatase Actin Regulator-1). We found that neuropilin-1 (NRP-1) and VEGF-R1 depletion inhibited Phactr-1 mRNA expression while NRP-2 and VEGF-R2 depletion had no effect. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PHACTR1
- 
- 