Relation Results

Summary

Name MKRN2
Full Name E3 ubiquitin-protein ligase makorin-2
Synonyms RING finger protein 62, RING-type E3 ubiquitin transferase makorin-2 | RNF62
Primary ID Q9H000
Links - -
Type protein
Relations 2
Function E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Promotes the polyubiquitination ...
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Type: Score: Layout: SPV 
0.3420.2MKRN2RELAUb:E2

Relations

Regulator
Mechanism
target
score
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination RELA 0.342
Identifier Residue Sequence Organism Cell Line
SIGNOR-278591 Homo sapiens
pmid sentence
MKRN2 promotes p65 ubiquitination and degradation through RING finger domain.
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination MKRN2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271220 Homo sapiens
pmid sentence
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t
Publications: 1 Organism: Homo Sapiens
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