| + |
NSD1 | up-regulates 
methylation
|
RELA |
0.475 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163454 |
Lys218 |
EIFLLCDkVQKEDIE |
Homo sapiens |
|
| pmid |
sentence |
| 20080798 |
Fbxl11 and nsd1 have opposite effects on nf-kb; both bind to p65 subunit after activation of nf-kb. / nsd1 activates nf-kb and reverses the inhibitory effect of fbxl11 / these data confirm that fbxl11 and nsd1 constitute an enzyme pair that methylates and demethylates p65 on k218 and 221 in response to cytokine stimulation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163458 |
Lys221 |
LLCDKVQkEDIEVYF |
Homo sapiens |
|
| pmid |
sentence |
| 20080798 |
Fbxl11 and nsd1 have opposite effects on nf-kb; both bind to p65 subunit after activation of nf-kb. / nsd1 activates nf-kb and reverses the inhibitory effect of fbxl11 / these data confirm that fbxl11 and nsd1 constitute an enzyme pair that methylates and demethylates p65 on k218 and 221 in response to cytokine stimulation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
KDM2A | down-regulates 
demethylation
|
RELA |
0.471 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163384 |
Lys218 |
EIFLLCDkVQKEDIE |
Homo sapiens |
|
| pmid |
sentence |
| 20080798 |
Fbxl11 and nsd1 have opposite effects on nf-kb; both bind to p65 subunit after activation of nf-kb. / nsd1 activates nf-kb and reverses the inhibitory effect of fbxl11 / these data confirm that fbxl11 and nsd1 constitute an enzyme pair that methylates and demethylates p65 on k218 and 221 in response to cytokine stimulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPGRIP1L | down-regulates
demethylation
|
RELA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163320 |
Lys221 |
LLCDKVQkEDIEVYF |
Homo sapiens |
|
| pmid |
sentence |
| 20080798 |
Fbxl11 and nsd1 have opposite effects on nf-kb; both bind to p65 subunit after activation of nf-kb. / nsd1 activates nf-kb and reverses the inhibitory effect of fbxl11 / these data confirm that fbxl11 and nsd1 constitute an enzyme pair that methylates and demethylates p65 on k218 and 221 in response to cytokine stimulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EP300 | up-regulates activity
acetylation
|
RELA |
0.814 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238778 |
Lys310 |
KRTYETFkSIMKKSP |
Homo sapiens |
NCI-H460 Cell |
| pmid |
sentence |
| 15152190 |
Using acetylation assays, p300 was found to effectively acetylate RelA/p65 across the amino-acid region containing 1317 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
SIRT1 | down-regulates activity
deacetylation
|
RELA |
0.715 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238817 |
Lys310 |
KRTYETFkSIMKKSP |
Homo sapiens |
NCI-H460 Cell |
| pmid |
sentence |
| 15152190 |
SIRT1 physically interacts with the RelA/p65 subunit of NF-kappaB and inhibits transcription by deacetylating RelA/p65 at lysine 310. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
PRKACA | up-regulates
phosphorylation
|
RELA |
0.494 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-58972 |
Ser276 |
SMQLRRPsDRELSEP |
Homo sapiens |
|
| pmid |
sentence |
| 9660950 |
The transcriptional activity of nf-kappa b is stimulated upon phosphorylation of its p65 subunit on serine 276 by protein kinase a (pka). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6KA4 | up-regulates
phosphorylation
|
RELA |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151436 |
Ser276 |
SMQLRRPsDRELSEP |
Homo sapiens |
|
| pmid |
sentence |
| 17183360 |
Rela is phosphorylated at: ser276 by the catalytic subunit of protein kinase a (pkac), msk1 and msk2; at ser311 by the atypical pkczeta; at ser468 by ikkbeta, ikkepsilon and glycogen-synthase kinase-3beta (gsk3beta); at ser529 by ck2; and at ser536 by ikkbeta, ikkalfa, ikkepsilon, nf-kb activating kinase (nak, also known as tank-binding kinase-1 tbk1)) and rsk1 (also known as p90 ribosomal protein s6 kinase (p90s6k) msk 1 and 2 can directly phosphorylate and activate transcription factors such as creb, atf1, the nf-kb isoform p65 and stat 1 and 3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIM1 | up-regulates
phosphorylation
|
RELA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-189125 |
Ser276 |
SMQLRRPsDRELSEP |
Homo sapiens |
|
| pmid |
sentence |
| 19911008 |
In this study we show that phosphorylation of rela/p65 at ser276 prevents its degradation by ubiquitin-mediated proteolysis. importantly, we identify pim-1 as a further kinase responsible for the phosphorylation of rela/p65 at ser276. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
PPM1A | down-regulates activity
dephosphorylation
|
RELA |
0.361 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276963 |
Ser276 |
SMQLRRPsDRELSEP |
Homo sapiens |
|
| pmid |
sentence |
| 23812431 |
23 Here we show that PPM1A directly dephosphorylated RelA at S536 and S276, with resultant inhibition of NF-kappaB transactivation and decreased expression of target genes, notably including MCP-1 and CCL2.|Taken together, these data suggest that dephosphorylation of S276 by PPM1A may contribute to inhibit RelA transcriptional activity, but the majority of PPM1A activity to inhibit RelA transcription relies on dephos phorylation of S536 of RelA.|We show that PPM1A directly dephosphorylated RelA at residues S536 and S276 and selectively inhibited Nuclear factor-\u03baB transcriptional activity, resulting in decreased expression of monocyte chemotactic protein-1/chemokine (C-C motif) ligand 2 and interleukin-6, cytokines implicated in cancer metastasis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276964 |
Ser536 |
SGDEDFSsIADMDFS |
Homo sapiens |
|
| pmid |
sentence |
| 23812431 |
We show that PPM1A directly dephosphorylated RelA at residues S536 and S276 and selectively inhibited NF-kappaB transcriptional activity, resulting in decreased expression of monocyte chemotactic protein-1 and chemokine (C-C motif) ligand 2 and interleukin-6, cytokines implicated in cancer metastasis.|18 Wild-type, but not phosphatase-dead, PPM1A dephosphorylated the pS536 peptide with equivalent efficacy as the known RelA S536 phosphatase, Wip1 (XREF_FIG, compare lanes 4 and 7).|Taken together, these data suggest that dephosphorylation of S276 by PPM1A may contribute to inhibit RelA transcriptional activity, but the majority of PPM1A activity to inhibit RelA transcription relies on dephos phorylation of S536 of RelA. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
RPS6KA5 | up-regulates
phosphorylation
|
RELA |
0.706 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99210 |
Ser276 |
SMQLRRPsDRELSEP |
Homo sapiens |
|
| pmid |
sentence |
| 12628924 |
Transcriptional activation of the nf-kappab p65 subunit by mitogen- and stress-activated protein kinase-1 (msk1)mutational analysis of p65 revealed ser276 as a target for phosphorylation and transactivation in response to tnf. Moreover, we identified msk1 as a nuclear kinase for p65, since msk1 associates with p65 in a stimulus-dependent way and phosphorylates p65 at ser276. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIM | up-regulates
phosphorylation
|
RELA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259411 |
Ser276 |
SMQLRRPsDRELSEP |
Homo sapiens |
|
| pmid |
sentence |
| 19911008 |
In this study we show that phosphorylation of rela/p65 at ser276 prevents its degradation by ubiquitin-mediated proteolysis. importantly, we identify pim-1 as a further kinase responsible for the phosphorylation of rela/p65 at ser276. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
PRKCZ | up-regulates
phosphorylation
|
RELA |
0.536 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151432 |
Ser311 |
RTYETFKsIMKKSPF |
Homo sapiens |
|
| pmid |
sentence |
| 17183360 |
Rela is phosphorylated at: ser276 by the catalytic subunit of protein kinase a (pkac), msk1 and msk2; at ser311 by the atypical pkczeta; at ser468 by ikkbeta, ikkepsilon and glycogen-synthase kinase-3beta (gsk3beta); at ser529 by ck2; and at ser536 by ikkbeta, ikkalfa, ikkepsilon, nf-kb activating kinase (nak, also known as tank-binding kinase-1 tbk1)) and rsk1 (also known as p90 ribosomal protein s6 kinase (p90s6k) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSNK1A1 | up-regulates activity
phosphorylation
|
RELA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276916 |
Ser316 |
FKSIMKKsPFSGPTD |
in vitro |
|
| pmid |
sentence |
| 26082493 |
These data strongly suggested that CKI phosphorylated Ser-316 of p65. Our data suggested that phosphorylation of p65 on Ser-316 controls the activity and function of NF-κB. Importantly, we found that phosphorylation at the novel Ser-316 site and other two known phosphorylation sites, Ser-529 and Ser-536, either individually or cooperatively, regulated distinct groups of NF-κB-dependent genes, suggesting the unique role of each individual phosphorylation site on NF-κB-dependent gene regulation. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
IKBKB | up-regulates activity
phosphorylation
|
RELA |
0.882 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-138903 |
Ser468 |
AVFTDLAsVDNSEFQ |
Homo sapiens |
Breast Cancer Cell, T-lymphocyte |
| pmid |
sentence |
| 16046471 |
Rela is phosphorylated at ser536 by ikkbeta, ikkalfa, ikkepsilon, nf-kb activating kinase (nak, also known as tank-binding kinase-1 tbk1) and rsk1 (also known as p90 ribosomal protein s6 kinase (p90s6k). We now present evidence that suggests that the upstream kinase ikkbeta plays an important role in tax-induced p53 inhibition through phosphorylation of p65/rela at ser-536. Ikkbeta plays an important role in tax-induced p53 inhibition through phosphorylation of p65/rela at ser-536. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129935 |
Ser536 |
SGDEDFSsIADMDFS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15489227 |
Chromatographic fractionation of cell extracts allowed the identification of two distinct enzymatic activities phosphorylating ser-536. Peak 1 represents an unknown kinase, whereas peak 2 contained ikkalpha, ikkbeta, ikkepsilon, and tbk1. collectively, our results provide evidence for at least five kinases that converge on ser-536 of p65 and a novel function for this phosphorylation site in the recruitment of components of the basal transcriptional machinery to the interleukin-8 promoter. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
GSK3B | up-regulates
phosphorylation
|
RELA |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143581 |
Ser468 |
AVFTDLAsVDNSEFQ |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 16407239 |
Rela is phosphorylated at: ser276 by the catalytic subunit of protein kinase a (pkac), msk1 and msk2; at ser311 by the atypical pkczeta; at ser468 by ikkbeta, ikkepsilon and glycogen-synthase kinase-3beta (gsk3beta); at ser529 by ck2; and at ser536 by ikkbeta, ikkalfa, ikkepsilon, nf-kb activating kinase (nak, also known as tank-binding kinase-1 tbk1)) and rsk1 (also known as p90 ribosomal protein s6 kinase (p90s6k) . |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151422 |
Ser468 |
AVFTDLAsVDNSEFQ |
Homo sapiens |
|
| pmid |
sentence |
| 17183360 |
Rela is phosphorylated at: ser276 by the catalytic subunit of protein kinase a (pkac), msk1 and msk2; at ser311 by the atypical pkczeta; at ser468 by ikkbeta, ikkepsilon and glycogen-synthase kinase-3beta (gsk3beta); at ser529 by ck2; and at ser536 by ikkbeta, ikkalfa, ikkepsilon, nf-kb activating kinase (nak, also known as tank-binding kinase-1 tbk1)) and rsk1 (also known as p90 ribosomal protein s6 kinase (p90s6k) . |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
IKBKE | up-regulates
phosphorylation
|
RELA |
0.45 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129939 |
Ser468 |
AVFTDLAsVDNSEFQ |
Homo sapiens |
|
| pmid |
sentence |
| 15489227 |
Overexpressed ikkepsilon and tbk1 phosphorylate ser-536 in vivo and in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129943 |
Ser536 |
SGDEDFSsIADMDFS |
Homo sapiens |
|
| pmid |
sentence |
| 15489227 |
Overexpressed ikkepsilon and tbk1 phosphorylate ser-536 in vivo and in vitro. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CSNK2A1 | up-regulates activity
phosphorylation
|
RELA |
0.455 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-149635 |
Ser529 |
GLPNGLLsGDEDFSS |
Homo sapiens |
|
| pmid |
sentence |
| 10938077 |
Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II.|Furthermore, our results indicate that the association between IkappaBalpha and p65 inhibits p65 phosphorylation by CKII and that degradation of IkappaBalpha allows CKII to phosphorylate p65 to increase NF-kappaB transactivation potential. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250942 |
Ser543 |
SIADMDFsALLSQIS |
Homo sapiens |
|
| pmid |
sentence |
| 10938077 |
We demonstrate that casein kinase II (CKII) interacts with p65 in vivo and can phosphorylate p65 at serine 529 in vitro. A CKII inhibitor (PD144795) inhibited TNFalpha-induced p65 phosphorylation in vivo. Furthermore, our results indicate that the association between IkappaBalpha and p65 inhibits p65 phosphorylation by CKII and that degradation of IkappaBalpha allows CKII to phosphorylate p65 to increase NF-kappaB transactivation potential. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CSN1S1 | up-regulates
phosphorylation
|
RELA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-171222 |
Ser529 |
GLPNGLLsGDEDFSS |
Homo sapiens |
|
| pmid |
sentence |
| 21232017 |
Phosphorylation of serine 529 of p65 is mediated by casein kinase ii, but is prevented in nonstimulated cells by the interaction with ikba |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHUK | up-regulates activity
phosphorylation
|
RELA |
0.841 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132568 |
Ser536 |
SGDEDFSsIADMDFS |
Homo sapiens |
Monocyte |
| pmid |
sentence |
| 15611276 |
Our data suggest that the stimulation of nfkb by akt is dependent on the phosphorylation of p65 at s534, mediated by ikk (ikb kinase) alfa and beta. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-71270 |
Ser536 |
SGDEDFSsIADMDFS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10521409 |
Our data suggest that the stimulation of nfkb by akt is dependent on the phosphorylation of p65 at s534, mediated by ikk (ikb kinase) alfa and beta. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129931 |
Ser536 |
SGDEDFSsIADMDFS |
Homo sapiens |
HEK-293 Cell, HeLa Cell |
| pmid |
sentence |
| 15489227 |
Chromatographic fractionation of cell extracts allowed the identification of two distinct enzymatic activities phosphorylating ser-536. Peak 1 represents an unknown kinase, whereas peak 2 contained ikkalpha, ikkbeta, ikkepsilon, and tbk1. collectively, our results provide evidence for at least five kinases that converge on ser-536 of p65 and a novel function for this phosphorylation site in the recruitment of components of the basal transcriptional machinery to the interleukin-8 promoter. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
TBK1 | up-regulates
phosphorylation
|
RELA |
0.602 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129951 |
Ser536 |
SGDEDFSsIADMDFS |
Homo sapiens |
|
| pmid |
sentence |
| 15489227 |
Chromatographic fractionation of cell extracts allowed the identification of two distinct enzymatic activities phosphorylating ser-536. Peak 1 represents an unknown kinase, whereas peak 2 contained ikkalpha, ikkbeta, ikkepsilon, and tbk1. collectively, our results provide evidence for at least five kinases that converge on ser-536 of p65 and a novel function for this phosphorylation site in the recruitment of components of the basal transcriptional machinery to the interleukin-8 promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKBKG | up-regulates activity
phosphorylation
|
RELA |
0.857 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129947 |
Ser536 |
SGDEDFSsIADMDFS |
Homo sapiens |
|
| pmid |
sentence |
| 15489227 |
Chromatographic fractionation of cell extracts allowed the identification of two distinct enzymatic activities phosphorylating ser-536. Peak 1 represents an unknown kinase, whereas peak 2 contained ikkalpha, ikkbeta, ikkepsilon, and tbk1. collectively, our results provide evidence for at least five kinases that converge on ser-536 of p65 and a novel function for this phosphorylation site in the recruitment of components of the basal transcriptional machinery to the interleukin-8 promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GSK3A | up-regulates activity
phosphorylation
|
RELA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255827 |
Thr254 |
RQVAIVFRtPPYADPS |
Mus musculus |
Chondrocyte |
| pmid |
sentence |
| 22761446 |
Redundant functions of GSK-3_ and GSK-3_ through phosphorylation of RelA at Thr-254 play a crucial role in early stages of chondrocyte differentiation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
GSK3B | up-regulates activity
phosphorylation
|
RELA |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255828 |
Thr254 |
RQVAIVFRtPPYADPS |
Mus musculus |
Chondrocyte |
| pmid |
sentence |
| 22761446 |
Redundant functions of GSK-3_ and GSK-3_ through phosphorylation of RelA at Thr-254 play a crucial role in early stages of chondrocyte differentiation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia |
| + |
PPP4C | up-regulates activity
dephosphorylation
|
RELA |
0.368 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248549 |
Thr435 |
PTQAGEGtLSEALLQ |
Homo sapiens |
|
| pmid |
sentence |
| 15073167 |
Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RELA | up-regulates quantity by expression 
transcriptional regulation
|
TRAF1 |
0.531 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-59957 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9733516 |
Thus, our data indicate that nf-kb controls the expression of traf1 and traf2 and c-iap1 and c-iap2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EP300 | up-regulates
acetylation
|
RELA |
0.814 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143399 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16382138 |
Rela is also acetylated at several sites by p300 and cbp |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
MIIP | up-regulates activity
binding
|
RELA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273829 |
|
|
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 29038521 |
Here, we show that EGF stimulation induces PKCε-dependent phosphorylation of migration and invasion inhibitory protein (MIIP) at Ser303; this phosphorylation promotes the interaction between MIIP and RelA in the nucleus, by which MIIP prevents histone deacetylase 6 (HDAC6)-mediated RelA deacetylation, and thus enhances transcriptional activity of RelA and facilitates tumor metastasis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RELA | form complex 
binding
|
SNAIL/RELA/PARP1 |
0.453 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254527 |
|
|
Homo sapiens |
Fibroblast, Mesenchymal Cell |
| pmid |
sentence |
| 22223884 |
Therefore, we conclude that the endogenous proteins PARP1, p65NF-κB and Snail1 form a ternary complex in the nuclei of cells that are actively expressing fibronectin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TSC22D3 | down-regulates activity
binding
|
RELA |
0.381 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253297 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11468175 |
GILZ inhibits NF-kappaB nuclear translocation and DNA binding due to a direct protein-to-protein interaction of GILZ with the NF-kappaB subunits. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RELA | down-regulates quantity by repression
transcriptional regulation
|
BMP4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266087 |
|
|
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 17350185 |
Co-transfection with pCMV4-RelA alone or in combination with pCMV4p50 repressed pSLA4.1 EX-Lux activity by approximately 75 percent in both H441 and A549 cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MIPOL1 | down-regulates activity 
|
RELA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261136 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31609475 |
In our results, we also showed that re-expression of MIPOL1 is associated with suppression phosphorylation of AKT and p65, a subunit of NF-ҡB. This suggests that MIPOL1 may inhibit invasion by suppression of phosphorylation of AKT and p65 to further inhibit the expression of MMP-9 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RELA | up-regulates quantity by expression
transcriptional regulation
|
BCL2A1 |
0.5 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-65020 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 10049356 |
Here we show thata1,abcl-2homolog up-regulated in primary lymphocytes by different mitogens, represents a novel class of rel/nf-kb-regulated prosurvival genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFKB1 | up-regulates activity
binding
|
RELA |
0.699 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-55378 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9450761 |
Here we report the crystal structure at 2.9 a resolution of the p50/p65 heterodimer bound to the kappab dna |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NLRX1 | up-regulates activity
relocalization
|
RELA |
0.262 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260358 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 18219313 |
NLRX1 synergistically potentiated ROS production induced by tumour necrosis factor alpha, Shigella infection and double-stranded RNA, resulting in amplified NF-kappaB-dependent and JUN amino-terminal kinases-dependent signalling. We observed that NLRX1-positive cells showed increased p65 translocation as early as 15 min after infection, an effect that was maintained over time. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RELA | up-regulates quantity
transcriptional regulation
|
MET |
0.253 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241929 |
|
|
Mus musculus |
HEPA 1-6 Cell |
| pmid |
sentence |
| 19530226 |
Together, these results indicate that the Met gene is a direct target of NFkappaB and that Met participates in NFkappaB-mediated cell survival. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
RELA | up-regulates
binding
|
EGR1 |
0.444 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75001 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10671503 |
The early growth response transcription factor egr-1 can also interact with rela in vitro and regulate nf-kappab transcriptional activity in vivo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RELA | up-regulates
binding
|
CITED1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-59054 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9660950 |
The transcriptional coactivator cpb/p300 associates with nf-kappa b p65 through two sites, an n-terminal domain that interacts with the c-terminal region of unphosphorylated p65, and a second domain that only interacts with p65 phosphorylated on serine 276. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RELA | up-regulates
binding
|
SP1 |
0.614 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75004 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10671503 |
Rela (p65) nf-kappab subunit interacts with the zinc finger dna-binding domain of sp1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
RELA | up-regulates quantity by expression
transcriptional regulation
|
IL6 |
0.681 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266088 |
|
|
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 17350185 |
The IL-6 promoter was stimulated by NF-kB RelA protein. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251737 |
|
|
Mus musculus |
Macrophage |
| pmid |
sentence |
| 27337441 |
Recent reports show that in mice the microbiome, comprising commensal microorganisms that colonize body surfaces, promotes a partial and low-grade M1-like phenotype in macrophages throughout the body, including those in lymphoid organs (119, 120). This M1-like priming of macrophages induces chromatin remodeling with increased H3K4me3 marks at Ifnb, Il6, and Tnf promoters, which is associated with increased binding of NF-κB p65, IRF3, and Pol II upon cell stimulation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| + |
PCSK7 | up-regulates
|
RELA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235734 |
|
|
Mus musculus |
C2C12 Cell, Myoblast |
| pmid |
sentence |
| 14767066 |
Treatment with sb203580 significantly reduced this cooperation, consistent with the idea that p38 indirectly stimulates the transactivating activity of p65 through a mechanism involving cbp. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
RELA | up-regulates
binding
|
CREBBP |
0.874 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-66953 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10207072 |
Both p53 and rela(p65) interact with the transcriptional coactivator proteins p300 and creb-binding protein (cbp), and we demonstrate that these results are consistent with competition for a limiting pool of p300/cbp complexes in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RELA | form complex
binding
|
NfKb-p65/p50 |
0.699 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-55381 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9450761 |
Here we report the crystal structure at 2.9 a resolution of the p50/p65 heterodimer bound to the kappab dna |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
RELA | up-regulates quantity by expression
transcriptional regulation
|
B2M |
0.265 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254657 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12480693 |
The nuclear factor kappa B (NF-kappa B) subunits p50 and p65 bind to the kappa B box and p65 transactivates beta(2)m. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RELA | down-regulates activity
relocalization
|
NCOR2 |
0.413 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261539 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 14982881 |
Furthermore, overexpression of Flt3-ITD led to a partial relocalization of SMRT protein from the nucleus to the cytoplasm. This indicates that shuttling of p65 was necessary for Flt3-ITD-mediated SMRT nuclear export. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
STAT1 | down-regulates
binding
|
RELA |
0.533 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-144561 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16481475 |
Acetylated stat1 is able to interact with nf-kappab p65. As a consequence, p65 dna binding, nuclear localization, and expression of anti-apoptotic nf-kappab target genes decrease. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RELA | down-regulates quantity by repression
transcriptional regulation
|
COMT |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251964 |
|
|
Homo sapiens |
Astrocytoma Cell |
| pmid |
sentence |
| 19291302 |
TNFα-dependent COMT downregulation was indeed mediated by the NF-κB pathway. Transient expression of p65, the essential component of NF-κB complexes, or IKKβ, the major positive regulator of NF-κB activition, significantly decreased P2-COMT reporter expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RELA | up-regulates
binding
|
HDAC4 |
0.322 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-138368 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15988006 |
P65 and histone deacetylases 4 cooperate to inhibit the ability of mef2 factors to induce the klf2 promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RELA | down-regulates activity
transcriptional regulation
|
IL1B |
0.537 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251736 |
|
|
Mus musculus |
Macrophage |
| pmid |
sentence |
| 23667107 |
Early Inhibition of IL-1 beta Expression by IFN-gamma Is Mediated by Impaired Binding of NF-kappa B to the IL-1 beta Promoter but Is Independent of Nitric Oxide|We report that IFN-γ suppressed bacterial RNA and LPS induced IL-1β transcription in primary murine macrophages |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
RELA | up-regulates quantity by expression
transcriptional regulation
|
CD80 |
0.301 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253935 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12860928 |
Upon CD40 signaling, transcription of the CD80 gene is induced by the nuclear factor (NF)-kappaB transcription factor. Our results show that BCL6 prevents CD40-induced expression of CD80 by binding its promoter region in vivo and suppressing its transcriptional activation by NF-kappaB. Consistent with a physiologic role for BCL6 in suppressing CD80, the expression of these two genes is mutually exclusive in B cells, and BCL6-defective mice show increased expression of CD80 in B cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
RELA |
transcriptional regulation
|
NPPB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253651 |
|
|
|
|
| pmid |
sentence |
| 15837525 |
In comparison to the ANF gene, less is known about BNP promoter consensus elements that regulate gene expression by mechanical or neurohumoral agonists. A number of cis-acting elements for GATA, Nkx2.5, NF-kappaB and TEF transcription factors have recently been identified within the BNP promoter that regulate BNP expression in response to specific agonists. This review focuses on the information available regarding cis-acting determinants responsible for inducible BNP transcription. |
|
| Publications: |
1 |
| + |
RELA | form complex
binding
|
REL/RELA |
0.66 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-46948 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9056676 |
Tnf-alpha induces the formation of a specific kappab binding complex, mainly composed of nf-kappab subunits rela and c-rel. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
| + |
RELA | up-regulates quantity by expression
transcriptional regulation
|
TRAF2 |
0.516 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-59960 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9733516 |
Thus, our data indicate that nf-kb controls the expression of traf1 and traf2 and c-iap1 and c-iap2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFKBIA | up-regulates activity
binding
|
RELA |
0.887 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-17691 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1340770 |
Nf-kappa b is an inducible transcription factor comprised of a 50-kd (p50) and a 65-kd (p65) subunit. Induction of nf-kappa b activity, which is a critical event in many signal transduction pathways, involves release from a cytoplasmic inhibitory protein, i kappa b, followed by translocation of the active transcription factor complex into the nucleus. we demonstrate by in vitro and in vivo methods that the recently cloned i kappa b/mad-3 interacts with both the p50 and p65 subunits of nf-kappa b. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2CA | down-regulates
dephosphorylation
|
RELA |
0.471 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-110959 |
|
|
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 11591705 |
Rela was dephosphorylated by a purified pp2a core enzyme, a heterodimer formed by the catalytic subunit of pp2a (pp2ac) and pr65, in a concentration-dependent manner.These data suggest that the constitutive activation of rela in melanoma cells could be due, at least in part, to the deficiency of pp2a, which exhibits decreased dephosphorylation of nf-kappa b/rela. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREBBP | up-regulates
acetylation
|
RELA |
0.874 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143396 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16382138 |
Rela is also acetylated at several sites by p300 and cbp |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PDLIM2 | down-regulates quantity by destabilization
polyubiquitination
|
RELA |
0.356 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271651 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17468759 |
Here we report that PDLIM2 negatively regulated NF-kappaB activity, acting as a nuclear ubiquitin E3 ligase targeting the p65 subunit of NF-kappaB. PDLIM2 bound to p65 and promoted p65 polyubiquitination. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RELA | up-regulates
binding
|
CBP/p300 |
0.844 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217655 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10207072 |
Both p53 and rela(p65) interact with the transcriptional coactivator proteins p300 and creb-binding protein (cbp), and we demonstrate that these results are consistent with competition for a limiting pool of p300/cbp complexes in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RELA | up-regulates quantity by expression
transcriptional regulation
|
IL1B |
0.537 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256237 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20975042 |
In addition, we show that the transcription of IL1B depends on a positively acting p65/c-Rel/ikbb complex |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MEN1 | down-regulates
binding
|
RELA |
0.475 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-110067 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11526476 |
Menin represses p65-mediated transcriptional activation on nf-kappab sites in a dose-dependent and specific manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
RELA | up-regulates
binding
|
JUN |
0.708 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-160330 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18174238 |
Chromatin immunoprecipitation (chip) analysis confirmed the serum-induced recruitment of jund to the promoter in vivo and showed that the presence of jund was dependent on the presence of p65 and p50, indicating a protein-protein-dependent mechanism of jund recruitment |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
HDAC1 | down-regulates
binding
|
RELA |
0.588 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151425 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17183360 |
Phosphorylation at thr505 by the chk1 inhibits rela transactivation and results in its increased association with hdac1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RELA | down-regulates quantity by repression
transcriptional regulation
|
PCK2 |
0.27 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255072 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20137375 |
NF-kappaB p65 was shown to inhibit transcription of phosphoenolpyruvate carboxykinase (PEPCK), a rate-limiting enzyme in gluconeogenesis in the liver |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Liver |
| + |
PAK5 | up-regulates activity
phosphorylation
|
RELA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275657 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 29041983 |
PAK5-mediated phosphorylation and nuclear translocation of NF-κB-p65 promotes breast cancer cell proliferation in vitro and in vivo|We characterized that PAK5 could promote the phosphorylation and the nuclear translocation of p65 subunit of nuclear factor-kappaB, and demonstrated that p65 could directly bind to the promoter of Cyclin D1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RELA | up-regulates quantity by expression
transcriptional regulation
|
IEX-1L |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-59542 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9703517 |
Transcription factors of the nuclear factor-kappab/rel (nf-kappab) family may be important in cell survival by regulating unidentified, anti-apoptotic genes. One such gene that protects cells from apoptosis induced by fas or tumor necrosis factor type alpha (tnf), iex-1l, is described here. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CBP/p300 | up-regulates
acetylation
|
RELA |
0.844 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217210 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16382138 |
Rela is also acetylated at several sites by p300 and cbp |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
RELA
- 
- 